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IGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a modified analogue of Insulin-like Growth Factor 1 designed for extended activity and improved stability in research environments. It is structurally similar to naturally occurring IGF-1, a hormone involved in growth, cellular repair, and anabolic signalling.
The LR3 modification increases its half-life and reduces binding to IGF-binding proteins, allowing for prolonged biological activity in experimental models
Price range: R400,00 through R1 950,00
Key Research Areas & Observed Effects
In laboratory and preclinical research, IGF-1 LR3 has been associated with:
Stimulation of cellular growth and regeneration pathways
Support for muscle cell proliferation in experimental models
Influence on protein synthesis and recovery mechanisms
Interaction with insulin and glucose metabolism pathways
Potential support for tissue repair and regeneration research
Enhanced anabolic signalling activity due to prolonged receptor interaction
Most findings are based on animal and in vitro studies, with limited controlled human research available.
Mechanism of Action (Research Insights)
IGF-1 LR3 works primarily through interaction with the IGF-1 receptor:
IGF-1 Receptor Activation:
It binds to IGF-1 receptors on cells, activating signalling pathways involved in growth and cellular repair.
Anabolic Signalling:
Research shows activation of pathways such as PI3K/Akt and MAPK, which are linked to protein synthesis, cell growth, and recovery.
Extended Activity:
The LR3 modification reduces binding affinity to IGF-binding proteins, increasing bioavailability and extending activity duration.
Metabolic Interaction:
IGF-1 LR3 may influence glucose uptake and insulin-related pathways in experimental settings.
Scientific Applications
IGF-1 LR3 is commonly studied in research involving:
Muscle growth and recovery models
Tissue regeneration studies
Cellular growth signalling
Metabolic and glucose regulation research
Performance and anabolic pathway investigations
It is frequently explored in advanced peptide and growth-factor research due to its potent biological activity.
Summary
IGF-1 LR3 is a long-acting analogue of IGF-1 widely studied for its role in anabolic signalling, cellular repair, and metabolic regulation. Its extended activity profile makes it a significant focus in growth-factor research, though comprehensive human safety and efficacy data remain limited.
Important Disclaimer
IGF-1 LR3 is a research compound and is not approved for human use by authorities such as the FDA or SAHPRA.
Due to its potent biological activity and effects on growth-related pathways, it should be handled strictly within controlled laboratory and research environments.
This information is provided for scientific and educational purposes only and does not constitute medical advice.
Reconstitution Guide:
Add bacteriostatic water carefully to achieve the desired concentration. Allow the peptide to dissolve gently—avoid vigorous shaking.
Storage Guidelines:
Unreconstituted: Store frozen for long-term stability
Reconstituted: Refrigerate (2–8 °C) and use within recommended timeframes
Protect from light and avoid repeated freeze-thaw cycles
