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Melanotan II is a synthetic peptide analogue of alpha-melanocyte-stimulating hormone, a naturally occurring hormone involved in pigmentation and appetite regulation. It was originally developed for research into skin pigmentation and photoprotection.
Due to its interaction with melanocortin receptors, Melanotan II has been widely studied for its effects on melanin production and related biological pathways.
Price range: R400,00 through R450,00
Key Research Areas & Observed Effects
In laboratory and preclinical research, Melanotan II has been associated with:
Stimulation of melanin production in skin cells
Increased pigmentation response in experimental models
Interaction with appetite-regulating pathways
Influence on melanocortin receptor activity
Potential photoprotective effects in controlled studies
Most findings are derived from animal and early-stage research, with limited controlled human data.
Mechanism of Action (Research Insights)
Melanotan II acts on the body’s melanocortin system:
Melanocortin Receptor Activation:
It binds primarily to melanocortin receptors (such as MC1R), which are involved in regulating skin pigmentation.
Melanin Production:
Activation of these receptors can stimulate melanocytes to produce more melanin, the pigment responsible for skin colour.
Systemic Effects:
Because melanocortin receptors are present in multiple tissues, research has explored broader effects including appetite and other physiological responses.
Scientific Applications
Melanotan II is studied in research areas including:
Skin pigmentation and dermatology
UV response and photoprotection
Melanocortin receptor biology
Appetite and metabolic research
Hormonal signalling pathways
Its activity across multiple receptor systems makes it relevant in various experimental fields.
Summary
Melanotan II is a synthetic peptide widely studied for its role in melanin production and melanocortin receptor activity. While research has shown notable effects in controlled settings, comprehensive human safety and efficacy data remain limited, and further study is required.
Important Disclaimer
Melanotan II is a research compound and is not approved for human use by regulatory authorities such as the FDA or SAHPRA.
It is not licensed as a cosmetic or medical product. All information provided is intended strictly for scientific and educational purposes and should not be interpreted as medical advice.
Reconstitution Guide:
Add bacteriostatic water to achieve the desired concentration. Allow to dissolve gently—do not shake.
Storage Guidelines:
Unreconstituted: Store in a cool, dry, dark environment or frozen for long-term stability
Reconstituted: Refrigerate (2–8 °C) and use within recommended timeframes
Protect from light and avoid repeated freeze-thaw cycles
